Benzocaine occurs in two forms: a crystalline salt (benzocaine HCl) that is soluble in water at 0.4 g/L, and a nonwater-soluble basic form that must be dissolved in ethyl alcohol at a concentration of 0.2 g/ml before it is sufficiently soluble in water to create a functional induction dose.

What functional group is in Benzocaine?

Functional GroupAbsorption Frequency cm-1Aromatic C-H3300 – 3000Aromatic C-C Double Bond1600, 1580, 1500, 1450C-O Double Bond1735CH31470 – 1430, 1380 – 1370

What is the pKa of benzocaine?

Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.

What is benzocaine made up of?

Benzocaine is a chemical compound derived from para-aminobenzoic acid and ethanol. It is a white, odorless, crystalline powder. It acts on neuronal membranes and blocks nerve signals in the body. Its numbing effects are temporary.

Can I use benzocaine while pregnant?

Benzocaine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Benzocaine should be given to a pregnant woman only if clearly needed.

What is the conjugate acid of benzocaine?

(2) Look up the structures and melting points of the three compounds you will be separating in the second part. The pKa of benzoic acid is 4.2; the pKa of the conjugate acid of benzocaine is 2.5.

Is benzocaine soluble in HCL?

PropertyValueSourceWater Solubility2.85 mg/mLALOGPSlogP2.2ALOGPSlogP1.5ChemAxonlogS-1.8ALOGPS

Is benzocaine an antihistamine?

Benzocaine/pyrilamine/zinc oxide is a topical anesthetic, antihistamine, and skin protectant combination. It works by numbing the skin and reducing swelling.

Is Benzocaine a liquid?

Facts about benzocaine and prescription local anesthetics Benzocaine products are available as gels, sprays, ointments, solutions, and lozenges.

What is another name for benzocaine?

Clinical dataTrade namesAnbesol, Lanacane, Orajel, othersAHFS/Drugs.comMonographRoutes of administrationTopical, Oral

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What is benzocaine used for?

It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.

What happens if you use too much benzocaine?

An overdose of benzocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

Is benzocaine organic or inorganic?

Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. Benzocaine is an ester, a compound made from the organic acid PABA (para-aminobenzoic acid) and ethanol.

How is benzocaine metabolized?

Benzocaine is metabolized into at least three compounds by acetylation and hydrolysis. Benzocaine and its acetylated metabolite are rapidly eliminated across the gills while the more polar de-ethylated and de-ethylated-acetylated metabolites are excreted at slower rates primarily in the urine.

Does benzocaine affect sperm?

Studies have not been done to see if benzocaine could affect male fertility or increase the chance of birth defects. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy.

Is benzocaine safe while nursing?

Breastfeeding while taking benzocaine: Benzocaine has not been well studied for use during breastfeeding. However, as long as benzocaine is not applied to the breast or nipple so that a nursing child could not get it in their mouth, it should be okay to continue to breastfeed. Wash hands well after using benzocaine.

What is category C pregnancy?

Category C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

How does benzocaine work chemistry?

Benzocaine is an ester of paraaminobenzoic acid, lacking the terminal diethylamino group of procaine, with anesthetic activity. Benzocaine binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

Does benzocaine react with HCL?

The Benzocaine reacts with hydrochloric acid to form benzocaine hydrochloride.

Is benzocaine soluble in ethyl acetate?

The solubility of both polymorphs has been determined in eight pure organic solvents over the temperature range 278 K–323 K by a gravimetric method. The mole fraction solubility of benzocaine decreases in the order: 1,4-dioxane, acetone, ethyl acetate, chloroform, acetonitrile, methanol, n-butanol and toluene.

What is the conjugate base of acetylsalicylic acid?

CHEBI:13719 – acetylsalicylate. A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.

Do bases Deprotonate?

Bases used to deprotonate depend on the pKa of the compound. When the compound is not particularly acidic, and, as such, the molecule does not give up its proton easily, a base stronger than the commonly known hydroxides is required. Hydrides are one of the many types of powerful deprotonating agents.

Is it illegal to have benzocaine?

7. Benzocaine and lidocaine are however legal to import and sell as bulk chemicals. They are used within the pharmaceutical industry as active substances in a number of medicinal products.

What class drug is Topicort?

Topicort is a prescription medicine used to treat the symptoms of Corticosteroid-Responsive Dermatoses. Topicort may be used alone or with other medications. Topicort belongs to a class of drugs called Corticosteroids, Topical.

Is benzocaine safe than lidocaine?

“The study showed that benzocaine generated much more methemoglobin than lidocaine in a red blood cell model.” The FDA concluded its drug safety communication by urging health care professionals and consumers to report adverse reactions involving benzocaine or other medicines to the FDA’s MedWatch program.

What's better benzocaine or lidocaine?

Lidocaine and benzocaine were equally efficient, and both were better than placebo in reducing pain caused by insertion of needles into the palate.

Is benzocaine the same as lidocaine?

Lidocaine also comes in a systemic injection that’s used to treat cardiac rhythm problems. Benzocaine is more commonly used in throat lozenges and as a spray. Lidocaine and benzocaine are equally effective for pain relief. Both drugs have similar side effects, most commonly stinging or local skin issues.

Is benzocaine good for hemorrhoids?

Hemorrhoid treatments PI – UpToDate. Benzocaine, dibucaine, and lidocaine can help with pain and itching, but should not be used without talking to a doctor first. They should only be used once in a while, in small amounts.

Is Kanka safe to use?

KANK-A used in the mouth may cause a condition in which the oxygen in your body tissues can become dangerously low. This is a potentially fatal condition called methemoglobinemia (met-HEEM-oh glo-bin-EE-mee-a). Do not use this medicine if you have ever had methemoglobinemia.

Can Mucopain be swallowed?

Lozenges: Place Mucopain Gel 15 gm in mouth and allow it to dissolve slowly; do not chew, crush or swallow.

How much benzocaine is lethal?

Poisindex® states that the threshold toxic dose for benzocaine is 22-40 mg/kg.