Gran is short for granulocyte. The White Blood Count (WBC) in a blood test result is broken down into Granulocytes (GRAN) and Lymphocytes (LYM). White blood cells are part of the immune system. An elevated level of granulocytes is indicative of a bacterial infection.

What does it mean when Gran is high?

What Causes High Granulocytes? A high count of granulocytes in the blood is a condition called granulocytosis. This is the opposite of granulocytopenia, or low granulocytes, and is a concerning condition because it usually indicates an infection, autoimmune disease, or blood cell cancer.

When should I be concerned about immature granulocytes?

Immature granulocyte counts are often tests ordered for patients that are highly susceptible to develop infections. They may already have a suppressed immune system. When this test is run, if the result shows an increase, it means that the immune response will be severe.

Does immature granulocytes mean cancer?

Immature neutrophils are present in cancer and have an altered functional capacity compared to mature that may influence tumor progression. Immature neutrophils can be present and significantly increased in the peripheral blood and tissues of cancer patients.

What causes Granulocytopenia?

Granulocytopenia may result from congenital or acquired defective production of granulocyte precursors or it may be a consequence of increased destruction of mature granulocytes, most frequently caused by immune mechanisms.

What is normal WBC?

Normal Results The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L). Normal value ranges may vary slightly among different labs. Some labs use different measurements or may test different specimens. Talk to your provider about your test results.

What is the cause of high platelet count?

Infection. In both children and adults, infections are the most common cause of an elevated platelet count. 1 This elevation can be extreme, with platelet counts greater than 1 million cells per microliter.

Can lupus cause high immature granulocytes?

Patients with systemic lupus erythematosus (SLE) display increased numbers of immature neutrophils in the blood, but the exact role of these immature neutrophils is unclear.

What is normal range for IMM Gran?

Under normal conditions, the immature granulocyte percentage (IG%) in the blood is less than 1%. Immature granulocyte levels increase rapidly during infections, inflammation, or cancer [26, 29]. The normal range of granulocytes is 1.5 – 8.5 x 10^9/L. IG% should be <1.

Is it normal to have immature granulocytes in your blood?

Healthy individuals do not have immature granulocytes present in their peripheral blood. Therefore, the incidence of IGs in the peripheral blood is indicative of substantially increased bone marrow activation, as in different types of inflammation.

Article first time published on

What kind of infection causes immature granulocytes?

Granulocytosis and chronic myeloid leukemia (CML) CML causes a buildup of underdeveloped granulocytes in the bone marrow and bloodstream. Normally, bone marrow produces immature stem cells in a controlled way.

What is the difference between a granulocyte and an Agranulocyte?

Granulocytes are present in the cytoplasm in the form of granules whereas agranulocytes are present without the granules. Furthermore, granulocytes have four lobes, whereas agranulocytes are only single lobed.

What is Nrbc in blood test?

The term ‘NRBC’ – ‘nucleated red blood cells‘ – refers to precursor cells of the red blood cell lineage which still contain a nucleus; they are also known as erythroblasts or – obsolete – normoblasts. In healthy adults and older children, NRBC can only be found in blood-building bone marrow where they mature.

What drugs cause Granulocytopenia?

A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). These drugs include phenytoin, pyrimethamine, methotrexate, and cytarabine.

Does neutropenia go away?

Neutropenia can be caused by some viral infections or certain medications. The neutropenia is most often temporary in these cases. Chronic neutropenia is defined as lasting more than 2 months. It may eventually go away, or remain as a life-long condition.

Does agranulocytosis go away?

With timely treatment, the outlook for agranulocytosis is better. In many cases, the condition can be managed. People who develop agranulocytosis after a viral infection may even find that the condition resolves itself.

What should I do if my platelet count is high?

However, in some cases, high platelets may cause blood clotting, bleeding or stroke. Seek immediate medical care (call 911) if high platelets are accompanied by a persistent headache, difficulty breathing, dizziness, seizures, changes in speech, or confusion or loss of consciousness for even a brief moment.

What are the symptoms of high platelets?

The signs and symptoms of a high platelet count are linked to blood clots and bleeding. They include weakness, bleeding, headache, dizziness, chest pain, and tingling in the hands and feet.

What autoimmune disease causes high platelets?

Hughes syndrome, or antiphospholipid antibody syndrome (APS), is an autoimmune condition that causes thickening of the circulating blood. The immune system produces abnormal blood proteins called antiphospholipid antibodies, which cause blood platelets to clump together.

Is WBC 13.4 High?

The specific number for high white blood cell count varies from one lab testing facility to another, but a general rule of thumb is that a count of more than 10,500 leukocytes in a microliter of blood in adults is generally considered to be high, while 4,500-10,500 is considered within the normal range.

What is an alarming WBC count?

In general, for adults a count of more than 11,000 white blood cells (leukocytes) in a microliter of blood is considered a high white blood cell count.

Is a white blood cell count of 11.8 high?

Diagnosis of a high white blood cell count The normal range for your WBC is usually 4,500 to 11,000 cells per microliter. Your WBC is generally considered high if it is greater than 11,000 cells per microliter.

What is considered a high RDW?

A high RDW (over 14.5%) means that the red blood cells vary a lot in size. A normal RDW is 11.6 to 14.6%, but researchers from the Intermountain Medical Center Heart Institute found that patients with a RDW level greater than or equal to 12.9% had an increased risk for depression.

What happens if neutrophils are high?

If your neutrophil counts are high, it can mean you have an infection or are under a lot of stress. It can also be a symptom of more serious conditions. Neutropenia, or a low neutrophil count, can last for a few weeks or it can be chronic.

Would lupus show up on a CBC?

Diagnosis is based on several tests and excluding other conditions. Blood tests commonly included in a lupus panel include: Complete blood count (CBC) Antinuclear antibodies (ANA) and other antibody tests.

What test can confirm lupus?

The test you will hear about most is called the antinuclear antibodies test (the ANA test). 97% of people with lupus will test positive for ANA. ANA connect or bind to the nucleus or command center of the cell.

What autoimmune diseases cause high lymphocytes?

• Acute lymphocytic leukemia.
• Chronic lymphocytic leukemia.
• Cytomegalovirus (CMV) infection.
• Hepatitis A.
• Hepatitis B.
• Hepatitis C.
• HIV/AIDS.
• Hypothyroidism (underactive thyroid)

What is ABS IMM Gran in blood test?

Immature granulocytes are white blood cells that are immature. Small amounts of white blood cells may be present on a complete blood count test whether or not you have an infection although healthy people do not show immature granulocytes on their blood test report.

What is the function of granulocytes?

The primary function of granulocytes is the defense against invading microorganisms. The “cellular equipment” of these cells makes them well suited for this role. Granulocytes are recruited from the bone marrow on demand and proliferate from progenitor cells after infection.

What are granulocytes called?

A granulocyte is a type of white blood cell. Also called granular leukocyte, PMN, and polymorphonuclear leukocyte.

What happens if basophils count is high?

It can be caused by infections, severe allergies, or an overactive thyroid gland. An abnormally high basophil level is called basophilia. It can be a sign of chronic inflammation in your body. Or it can mean that a condition is causing too many white blood cells to be produced in your bone marrow.